ACE-031
Myostatin inhibitor · Also known as ACVR2B-Fc, Soluble Activin Receptor Type IIB
What is ACE-031?
A soluble activin receptor decoy that traps myostatin and other TGF-beta family ligands, preventing them from signaling muscle growth inhibition.
ACE-031 is a fusion protein combining the extracellular domain of the activin type IIB receptor with the Fc portion of an antibody. It acts as a trap for myostatin, activin, and GDF-11, all of which normally limit muscle growth.
Benefits & evidence
How it works
Myostatin is the body's natural brake on muscle growth. ACE-031 works as a decoy receptor that binds myostatin and related ligands before they can reach their actual receptors on muscle cells. With myostatin neutralized, muscle protein synthesis increases and muscle fibers grow larger.
In a Phase 2 trial for Duchenne muscular dystrophy, subjects gained an average of 1.7% lean body mass in just 4 weeks. However, the trial was halted due to minor nosebleeds and gum bleeding, likely from effects on blood vessel growth factors.
Dosing information
Typical dosing protocol
Not well established
Not well established
Clinical trials used IV infusions. No established subcutaneous dosing protocol.
Side effects
Most side effects tend to improve as your body adjusts.