FTPP
Proapoptotic peptide · Also known as Adipotide, FTPP Adipotide, Prohibitin-TP01
What is FTPP?
An experimental peptide that targets and destroys the blood supply to fat tissue, causing fat cells to die through apoptosis. Studied in primates with dramatic fat loss results.
FTPP is a chimeric peptide with two functional domains: one that homes to blood vessels feeding white adipose tissue, and another that triggers apoptosis in those endothelial cells. In rhesus monkeys, it caused 11% weight loss in 4 weeks.
Benefits & evidence
How it works
FTPP contains a targeting sequence (CKGGRAKDC) that binds to prohibitin on the surface of blood vessels supplying white fat tissue. Once bound, its second domain (a modified antimicrobial peptide) disrupts the cell membrane, triggering apoptosis in the endothelial cells.
Without blood supply, the fat cells die. In rhesus monkey studies, treated animals lost 11% body weight and 39% of their body fat in just 28 days. However, the peptide also caused reversible kidney damage.
Dosing information
Typical dosing protocol
Not well established
Not well established
Only tested in animal models. No human dosing data. Significant renal toxicity concern.
Side effects
Most side effects tend to improve as your body adjusts.