Neuropeptide · Also known as Kisspeptin, KP-10, Metastin
A neuropeptide that plays a central role in regulating the reproductive hormone cascade. It stimulates GnRH release, which triggers LH and FSH production.
Kisspeptin-10 is the bioactive fragment of the kisspeptin family. It acts on the KISS1R receptor in the hypothalamus to trigger GnRH release, making it a master regulator of reproductive function. Clinical research is exploring its use in fertility treatments and hormone diagnostics.
Kisspeptin binds to the KISS1R (GPR54) receptor on GnRH neurons in the hypothalamus. This triggers the release of gonadotropin-releasing hormone (GnRH), which in turn stimulates the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
This cascade is fundamental to reproductive function, puberty initiation, and sex hormone production. Researchers are particularly interested in kisspeptin because it sits upstream of the entire reproductive axis.
Not well established
Not well established
Most side effects tend to improve as your body adjusts.