NAD+
Coenzyme · Also known as Nicotinamide Adenine Dinucleotide, NAD
What is NAD+?
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell that plays a central role in energy metabolism, DNA repair, and cellular signaling. NAD+ levels decline with age, and supplementation aims to restore cellular function.
NAD+ is involved in hundreds of metabolic processes including converting food to energy, maintaining DNA integrity, and regulating circadian rhythms. Research suggests that boosting NAD+ levels may help counteract age-related cellular decline. NAD+ can be delivered via injection, nasal spray, oral supplements, or IV infusion.
Benefits & evidence
How it works
NAD+ serves as an electron carrier in mitochondria during cellular respiration, directly fueling ATP production. It also activates sirtuins, a family of proteins involved in DNA repair, inflammation control, and longevity pathways.
As a substrate for PARP enzymes, NAD+ supports DNA damage repair. It also regulates circadian clock proteins that control sleep-wake cycles and metabolic timing.
Dosing information
Typical dosing protocol
100-250mg injection or 100mg nasal spray
2-4 weeks250-500mg injection weekly or daily nasal spray
OngoingDosing varies significantly by delivery method. IV infusions use much higher doses (250-1000mg). Always follow prescriber guidance.
Prescription providers
Enhance MD
Yucca Health
Breeze Meds
Sprout Health
TMates
Peter MD
Strut Health
DudeMeds