4 peptides researched for sexual health.
Sexual health peptides target the neurological and vascular pathways involved in sexual arousal and function. Unlike PDE5 inhibitors (Viagra, Cialis) that work on blood flow mechanics, peptide-based approaches act through the central nervous system. specifically melanocortin receptors in the brain that regulate desire and arousal.
PT-141 (bremelanotide, brand name Vyleesi) is FDA-approved for hypoactive sexual desire disorder (HSDD) in premenopausal women. It activates melanocortin-4 receptors in the brain, working on sexual desire rather than just blood flow. Melanotan II also activates melanocortin receptors and was the precursor compound to PT-141, but it has broader effects. it also stimulates melanin production (tanning) and suppresses appetite. Melanotan II is not FDA-approved and carries more safety concerns, including risks of skin changes and cardiovascular effects.