BAM-15
Mitochondrial uncoupler · Also known as BAM15
What is BAM-15?
A small molecule mitochondrial uncoupler that increases energy expenditure by making mitochondria less efficient at producing ATP, causing more calories to be burned as heat.
BAM-15 selectively uncouples mitochondrial oxidative phosphorylation without depolarizing the plasma membrane. In mouse studies, it reduced body fat without affecting food intake or body temperature, and improved insulin sensitivity.
Benefits & evidence
How it works
Mitochondria produce ATP by maintaining a proton gradient across their inner membrane. BAM-15 allows protons to leak back across this membrane, uncoupling the gradient from ATP production. The energy is instead released as heat.
This forces cells to burn more fuel (glucose and fatty acids) to maintain energy levels, effectively increasing metabolic rate. Unlike the notoriously dangerous DNP, BAM-15 is selective for mitochondrial membranes and does not cause dangerous hyperthermia in animal studies.
Dosing information
Typical dosing protocol
Not well established
Not well established
Only tested in animal models. Oral bioavailability demonstrated in mice. No human dosing data.
Side effects
Most side effects tend to improve as your body adjusts.