SLU-PP-332
ERR agonist (exercise mimetic) · Also known as SLU-PP332, Exercise Mimetic Compound 332
What is SLU-PP-332?
A small molecule that activates estrogen-related receptors (ERRs) to mimic the molecular effects of exercise, including increased endurance, fat burning, and muscle fiber remodeling.
SLU-PP-332 activates all three estrogen-related receptors (ERRalpha, ERRbeta, ERRgamma), which are key regulators of energy metabolism normally activated by exercise. In mice, it increased running endurance by 50% and induced a shift toward fatigue-resistant muscle fibers.
Benefits & evidence
How it works
Exercise activates estrogen-related receptors (ERRs), which turn on genes involved in mitochondrial biogenesis, fatty acid oxidation, and muscle fiber type switching. SLU-PP-332 directly activates these same receptors without the need for physical exertion.
In mice, this resulted in a shift from fast-twitch to slow-twitch (fatigue-resistant) muscle fibers, increased mitochondrial density, and enhanced fat oxidation. Treated mice ran 50% longer on a treadmill test and resisted weight gain on a high-fat diet.
Dosing information
Typical dosing protocol
Not well established
Not well established
Only tested in animal models. No human trials conducted.
Side effects
Most side effects tend to improve as your body adjusts.