SNAP-8
Neuropeptide (topical cosmetic) · Also known as Acetyl Octapeptide-3, INCI Acetyl Octapeptide-3
What is SNAP-8?
An octapeptide that mimics the N-terminal end of SNAP-25, a protein involved in neurotransmitter release. Applied topically, it reduces the depth of expression wrinkles by modulating muscle contraction signals.
SNAP-8 is an elongated version of Argireline (Acetyl Hexapeptide-3) with two additional amino acids that increase its efficacy. It competes with natural SNAP-25 for a position in the SNARE complex, reducing the release of acetylcholine at neuromuscular junctions and softening muscle contractions that cause expression lines.
Benefits & evidence
How it works
Facial expression wrinkles form from repeated muscle contractions. The signal for muscle contraction requires the SNARE complex, which assembles from three proteins: SNAP-25, VAMP, and syntaxin. This complex enables vesicles of acetylcholine to fuse with the cell membrane and release the neurotransmitter.
SNAP-8 is a fragment that mimics part of SNAP-25. It competes for a position in the SNARE complex, forming a less functional version that reduces acetylcholine release. With less neurotransmitter reaching the muscle, contractions soften and wrinkle depth decreases.
This is the same mechanism as botulinum toxin (Botox) but much milder and reversible, working only on topically accessible superficial muscles.
Dosing information
Typical dosing protocol
Topical, 3-10% solution
Twice dailyTopical, 3-10% solution
OngoingApplied topically to expression lines (forehead, crow's feet, frown lines). Consistent use for 28+ days needed for visible results. Not injected.
Side effects
Most side effects tend to improve as your body adjusts.