GHK-Cu

Copper tripeptide complex · Also known as Copper peptide, "the glow peptide"

What is ghk-cu?

A naturally occurring copper peptide complex that declines with age. Studied for skin rejuvenation, wound healing, hair growth, and anti-aging effects.

GHK-Cu is a tripeptide with high affinity for copper. It's found naturally in human blood plasma, saliva, and urine, but levels decline significantly with age. Research suggests it can activate genes involved in tissue remodeling and repair.

Key takeaway: GHK-Cu is one of the few peptides with both topical and injectable evidence. It's particularly well-studied for skin and hair benefits.

Benefits & evidence

Skin rejuvenation Moderate confidence
Wound healing Moderate confidence
Hair growth Preliminary confidence
Anti-inflammatory Preliminary confidence

How it works

GHK-Cu delivers copper to cells, which is essential for many enzymatic processes including collagen synthesis, antioxidant defense, and wound repair. It activates genes responsible for tissue remodeling while suppressing genes linked to inflammation and tissue destruction. This dual action makes it effective for both repair and prevention of age-related decline.

Dosing information

Typical dosing protocol
Starting dose

1-2 mg/day (injectable) or topical application

Ongoing
Maintenance dose

1-2 mg/day

Ongoing

Available as injectable or topical cream/serum. Topical is most common for skin benefits. Consult your provider for injectable protocols.

Side effects

Most side effects tend to improve as your body adjusts.

Skin irritation (topical) Common
Injection site reaction Common
Mild nausea (injectable) Uncommon

Research (10 studies)

Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions. Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026