BPC-157

Gastric pentadecapeptide · Also known as Body Protection Compound-157

What is bpc-157?

A synthetic peptide derived from a protective protein found in human gastric juice. Studied extensively for tissue repair, gut healing, and injury recovery.

BPC-157 has shown remarkable healing properties in animal studies, accelerating recovery of muscles, tendons, ligaments, and the gastrointestinal tract. While human clinical data is still emerging, it remains one of the most popular recovery peptides.

Key takeaway: BPC-157 has strong preclinical evidence for tissue repair and gut healing, but human clinical trials are still limited. Most evidence comes from animal studies.

Benefits & evidence

Tendon & ligament repair Moderate confidence
Gut healing Moderate confidence
Muscle recovery Moderate confidence
Anti-inflammatory Preliminary confidence
Neuroprotection Preliminary confidence

How it works

BPC-157 appears to work through multiple mechanisms. It promotes angiogenesis (new blood vessel formation), modulates nitric oxide pathways, and upregulates growth factor receptors. This combination accelerates tissue repair by improving blood flow to injured areas and stimulating the body's natural healing processes.

It also has cytoprotective effects on the gut lining, which is why it's studied for conditions like leaky gut, inflammatory bowel issues, and NSAID-induced damage.

Dosing information

Typical dosing protocol
Starting dose

250 mcg/day

Weeks 1-2
Maintenance dose

250-500 mcg/day

4-12 weeks

Can be administered subcutaneously near injury site or orally for gut-related benefits. Consult your healthcare provider for appropriate protocol.

Side effects

Most side effects tend to improve as your body adjusts.

Injection site irritation Common
Mild nausea Common
Dizziness Uncommon
Fatigue Uncommon

Research (10 studies)

Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions. Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026
Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review. HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2025
Safety of Intravenous Infusion of BPC157 in Humans: A Pilot Study. Alternative therapies in health and medicine · 2025
Editorial Commentary: Testosterone, Growth Hormone, and Vitamin D Supplementation Is Not Routinely Indicated for Orthopaedic Surgery Patients. Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association · 2025