GLP-1 receptor agonist · Also known as Ozempic, Wegovy, Rybelsus
A synthetic peptide that mimics GLP-1, a naturally occurring hormone your body produces after eating. It works by telling your brain you're full, slowing digestion, and helping regulate blood sugar levels.
Originally developed for type 2 diabetes (marketed as Ozempic), semaglutide gained widespread attention when clinical trials showed remarkable weight loss results. It's now also available as Wegovy, specifically approved for chronic weight management.
Think of GLP-1 as your body's natural "I'm full" signal. When you eat, your gut releases GLP-1, which tells your brain to stop eating and signals your pancreas to manage blood sugar. The problem? Natural GLP-1 breaks down in minutes.
Semaglutide is engineered to last much longer. about a week. It binds to the same GLP-1 receptors but resists the enzymes that normally break it down. The result is a steady, sustained signal that helps reduce appetite, slow gastric emptying, and improve insulin sensitivity.
0.25 mg/week
Weeks 1-41.0-2.4 mg/week
After titration periodMost side effects tend to improve as your body adjusts.