CJC-1295

What is CJC-1295?

The short-acting form of CJC-1295, also known as Modified GRF 1-29. It has a half-life of about 30 minutes, producing sharp, natural-pattern growth hormone pulses when injected. Most commonly paired with ipamorelin.

CJC-1295 without DAC (Modified GRF 1-29) is a synthetic 29-amino-acid GHRH analog with four amino acid substitutions that protect it from enzymatic degradation. Unlike the DAC version, it clears quickly and produces acute GH spikes that closely mimic the body's natural pulsatile release pattern. This short half-life is actually an advantage for people who want to preserve normal GH physiology while boosting peak levels.

Benefits & evidence

How it works

CJC-1295 (no DAC) binds to GHRH receptors on pituitary somatotroph cells, stimulating them to synthesize and secrete growth hormone. Because it clears from the bloodstream in roughly 30 minutes, the resulting GH spike is sharp and brief, closely mimicking the body's natural pulsatile release.

This is a key difference from the DAC version, which binds to albumin and stays active for days, creating a sustained but non-pulsatile GH elevation. Many researchers prefer the no-DAC form precisely because it preserves the natural pulse pattern and feedback loops. It is almost always paired with a secretagogue like ipamorelin, which amplifies each GH pulse.

Dosing information

Side effects

Most side effects tend to improve as your body adjusts.

Research (13 studies)