Ipamorelin
Growth hormone secretagogue · Also known as IPAM, Ipamorelin acetate
What is Ipamorelin?
A selective growth hormone secretagogue that stimulates natural GH release without significantly affecting cortisol or prolactin levels.
Ipamorelin is a pentapeptide that selectively mimics ghrelin to stimulate growth hormone release from the pituitary gland. Unlike other GH secretagogues, it doesn't significantly raise cortisol, acetylcholine, prolactin, or aldosterone, making it one of the cleanest options in its class.
Benefits & evidence
How it works
Ipamorelin binds to ghrelin receptors in the pituitary gland, triggering a pulse of growth hormone release that mimics the body's natural rhythm. Its selectivity means it stimulates GH without the hunger spikes associated with GHRP-6 or the cortisol increases seen with GHRP-2.
Dosing information
Typical dosing protocol
100-200 mcg 2-3x daily
4-6 weeks200-300 mcg before bed
8-12 weeksOften stacked with CJC-1295 (no DAC) for enhanced GH pulse. Best administered on an empty stomach. Consult your provider for protocols.
Side effects
Most side effects tend to improve as your body adjusts.