Neuropeptide · Also known as Delta Sleep-Inducing Peptide
A naturally occurring neuropeptide first isolated from rabbit brain tissue in 1977. It promotes slow-wave (delta) sleep and modulates stress-related hormonal pathways, with additional research into its potential for treating withdrawal syndromes.
DSIP is a nine-amino-acid neuropeptide that crosses the blood-brain barrier and influences sleep architecture, stress response, and neuroendocrine regulation. Early clinical studies showed it could increase total sleep time and promote deeper sleep, though results across trials have been mixed. Notably, DSIP has shown promise in clinical trials for alleviating opioid and alcohol withdrawal symptoms. Its safety profile appears favorable. researchers have never been able to determine an LD50 in animal studies because no lethal dose could be established.
DSIP promotes sleep by enhancing slow-wave (delta) sleep patterns, reducing cortical arousal, and modulating levels of sleep-related hormones including melatonin. It interacts with NMDA receptors in the brain and potentiates GABAergic neurotransmission, both of which contribute to its sedative and anxiolytic effects.
Beyond sleep, DSIP modulates the hypothalamic-pituitary-adrenal (HPA) axis stress response by influencing corticotropin-releasing factor (CRF) pathways. It also acts antagonistically on opioid receptors, which explains its observed benefits in addiction withdrawal studies where it alleviated symptoms in a majority of opioid-dependent and alcohol-dependent patients.
100-200 mcg before bed
First 1-2 weeks200-300 mcg before bed
2-4 week cyclesMost side effects tend to improve as your body adjusts.