Thymic peptide / immune modulator · Also known as Zadaxin, Thymalfasin
A 28-amino-acid peptide naturally produced by the thymus gland that plays a central role in immune system regulation. Its synthetic form, thymalfasin, has been approved in over 35 countries for conditions including hepatitis B, hepatitis C, and as a vaccine adjuvant.
Thymosin Alpha-1 was first isolated from thymic tissue in the 1970s and its synthetic version (thymalfasin, marketed as Zadaxin) has become one of the most clinically studied immune-modulating peptides, with data from over 11,000 human subjects across more than 30 clinical trials. It has received orphan drug designation from the FDA for hepatocellular carcinoma and malignant melanoma, and is approved in over 35 countries for hepatitis B and C treatment, vaccine enhancement, and immune deficiency conditions.
Thymosin Alpha-1 acts as a master regulator of the immune system. It promotes the maturation of T cells in the thymus, specifically driving the development of CD4+ helper and CD8+ cytotoxic T cells. It also directly activates natural killer (NK) cells and enhances dendritic cell function, improving the body’s ability to detect and respond to pathogens and abnormal cells.
Beyond direct immune cell activation, Thymosin Alpha-1 modulates the balance between pro-inflammatory and anti-inflammatory responses. It increases production of key cytokines like interferon-alpha and interleukin-2 while helping prevent excessive inflammation. This dual role - boosting immune surveillance while maintaining balance - is why it has shown benefit across such a wide range of conditions, from chronic viral infections to cancer immunotherapy to vaccine enhancement.
1.6 mg twice weekly
Ongoing1.6 mg twice weekly
6-12 months typical courseMost side effects tend to improve as your body adjusts.